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Comparison of HER2-targeted affibody conjugates loaded with auristatinand maytansine-derived drugs
Authors: Wen Yin, Tianqi Xu, Haozhong Ding, Jie Zhang, Vitalina Bodenko, Maria S. Tretyakova c, Mikhail V. Belousov d,e, Yongsheng Liu b, Maryam Oroujeni b, Anna Orlova, Vladimir Tolmachev, Torbjörn Gräslund, Anzhelika Vorobyeva Abstracts: Treatment with antibody drug conjugates targeting receptors over-expressed on cancer cells is well established for clinical use in several types…
Novel Local “Off-the-Shelf” Immunotherapy for the Treatment of Myeloma Bone Disease
Authors: Sandra Charvátová , Benjamin Motais , Justyna Czapla, Tomasz Cichon, Ryszard Smolarczyk, ZuzanaWalek, Sebastian Giebel, Roman Hájek, and Juli R. Bagó Abstract: Myeloma bone disease (MBD) is one of the major complications in multiple myeloma (MM)—the second most frequent hematologic malignancy. It is characterized by the formation of bone lesions due to the…
Antitumor activity of the protein kinase inhibitor 1-(β-D-2′-deoxyribofuranosyl)-4,5,6,7- tetrabromo- 1H‑benzimidazole in breast cancer cell lines
Authors and Affiliations : Department of Biomedical Research, National Medicines Institute, Chełmska St. 30/34, 00-725, Warsaw, PolandMirosława KoronkiewiczInstitute of Chemistry, Warsaw University of Life Sciences, Nowoursynowska St. 159C, 02-787, Warsaw, PolandZygmunt Kazimierczuk & Andrzej Orzeszko Contributions : MK, AO contributed to the study conception. AO and ZK performed synthesis of compound. MK methodology. MK conducted the…
Porcine Serum, Trypsin and other Porcine-Derived Products : Swine Viruses of Importation and Adventitious Concern
Authors: Percy Hawkes The rapid and seemingly uncontrolled spread of African swine fever (ASF) throughout China and many of its neighboring countries within the last 19 months (August 2018-March 2020) has put the rest of the world on high alert. The geographic distribution of viruses of importation concern, like ASF virus (ASFV), can change…
Epigenomic study identifies a novel mesenchyme homeobox2- GLI1 transcription axis involved in cancer drug resistance, overall survival and therapy prognosis in lung cancer patients
Authors:Armas López Leonel, Piña-Sánchez Patricia, Arrieta Oscar, Guzman de Alba Enrique, Ortiz Quintero Blanca, Santillán Doherty Patricio, Christiani David C., Zúñiga Joaquín and Ávila-Moreno Federico Several homeobox-related gene (HOX) transcription factors such as mesenchyme HOX-2 (MEOX2) have previously been associated with cancer drug resistance, malignant progression and/or clinical prognostic responses in lung cancer patients;…
High-Quality FBS May Come from any Authorized Country of Origin
Authors: Percy W. Hawkes, DVM Read the publication in PDF