Authors: Wen Yin, Tianqi Xu, Haozhong Ding, Jie Zhang, Vitalina Bodenko, Maria S. Tretyakova c, Mikhail V. Belousov d,e, Yongsheng Liu b, Maryam Oroujeni b, Anna Orlova, Vladimir Tolmachev, Torbjörn Gräslund, Anzhelika Vorobyeva   Abstracts: Treatment with antibody drug conjugates targeting receptors over-expressed on cancer cells is well established for clinical use in several types of cancer, however, resistance often occurs motivating the development of novel drugs. We have recently investigated a drug conjugate consisting of an affibody molecule targeting the human epidermal growth factor receptor 2 (HER2), fused to an albumin-binding domain (ABD) for half-life extension, loaded with the cytotoxic maytansine derivative DM1. In this study, we investigated the…

Authors: Sandra Charvátová , Benjamin Motais , Justyna Czapla, Tomasz Cichon, Ryszard Smolarczyk, ZuzanaWalek, Sebastian Giebel, Roman Hájek, and Juli R. Bagó   Abstract: Myeloma bone disease (MBD) is one of the major complications in multiple myeloma (MM)—the second most frequent hematologic malignancy. It is characterized by the formation of bone lesions due to the local action of proliferating MM cells, and to date, no effective therapy has been developed. In this study, we propose a novel approach for the local treatment of MBD with a combination of natural killer cells (NKs) and mesenchymal stem cells (MSCs) within a fibrin scaffold, altogether known as FINM. The unique biological properties of…

Authors and Affiliations : Department of Biomedical Research, National Medicines Institute, Chełmska St. 30/34, 00-725, Warsaw, PolandMirosława KoronkiewiczInstitute of Chemistry, Warsaw University of Life Sciences, Nowoursynowska St. 159C, 02-787, Warsaw, PolandZygmunt Kazimierczuk & Andrzej Orzeszko   Contributions : MK, AO contributed to the study conception. AO and ZK performed synthesis of compound. MK methodology. MK conducted the all experiments. MK interpretation of data. MK writing-original draft preparation and editing. AO, MK reviewed the article. All authors read and approved the final manuscript.   Abstract : Background : The protein kinases CK2 and PIM-1 are involved in cell proliferation and survival, the cell cycle, and drug resistance, and they are found overexpressed in…

Authors: Percy Hawkes   The rapid and seemingly uncontrolled spread of African swine fever (ASF) throughout China and many of its neighboring countries within the last 19 months (August 2018-March 2020) has put the rest of the world on high alert. The geographic distribution of viruses of importation concern, like ASF virus (ASFV), can change very quickly, putting at risk conventional sources of porcine serum and other porcine-derived products used as ingredients in research, the manufacture of biologies, and other biomedical applications. This article reviews the 2019 information from the World Organization for Animal Health (OIE) regarding the pres­ence or absence of eight viruses of importation concern in the swine…

Authors:Armas López Leonel, Piña-Sánchez Patricia, Arrieta Oscar, Guzman de Alba Enrique, Ortiz Quintero Blanca, Santillán Doherty Patricio, Christiani David C., Zúñiga Joaquín and Ávila-Moreno Federico   Several homeobox-related gene (HOX) transcription factors such as mesenchyme HOX-2 (MEOX2) have previously been associated with cancer drug resistance, malignant progression and/or clinical prognostic responses in lung cancer patients; however, the mechanisms involved in these responses have yet to be elucidated. Here, an epigenomic strategy was implemented to identify novel MEOX2 gene promoter transcription targets and propose a new molecular mechanism underlying lung cancer drug resistance and poor clinical prognosis. Chromatin immunoprecipitation (ChIP) assays derived from non-small cell lung carcinomas (NSCLC) hybridized on gene…

Authors: Percy W. Hawkes, DVM Read the publication in PDF