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Licochalcone A Potently Inhibits Tumor Necrosis Factor α-Induced Nuclear Factor-κB Activation through the Direct Inhibition of IκB Kinase Complex Activation
Authors:Megumi Funakoshi-Tago, Saeko Tanabe, Kenji Tago, Hiroshi Itoh, Tadahiko Mashino, Yoshiko Sonoda and Tadashi Kasahara Glycyrrhiza inflata has been used as a traditional medicine with anti-inflammatory activity; however, its mechanism has not been fully understood. Licochalcone A is a major and biogenetically characteristic chalcone isolated from G. inflata. Here, we found that licochalcone A…
Long-term Cultures of Bone Marrow–Derived Human Mesenchymal Stem Cells Frequently Undergo Spontaneous Malignant Transformation
Authors:Gro Vatne Røsland, Agnete Svendsen, Anja Torsvik, Ewa Sobala, Emmet McCormack, Heike Immervoll, Josef Mysliwietz, Joerg-Christian Tonn, Roland Goldbrunner, Per Eystein Lønning, Rolf Bjerkvig, and Christian Schichor Human mesenchymal stem cells (hMSC) aid in tissue maintenance and repair by differentiating into specialized cell types. Due to this ability, hMSC are currently being evaluated for…
Human Hematopoietic Stem Cells Can Survive In Vitro for Several Months
Authors:Taro Ishigaki, Kazuhiro Sudo, Takashi Hiroyama, Kenichi Miharada, Haruhiko Ninomiya, Shigeru Chiba, Toshiro Nagasawa, and Yukio Nakamura We previously reported that long-lasting in vitro hematopoiesis could be achieved using the cells differentiated from primate embryonic stem (ES) cells. Thus, we speculated that hematopoietic stem cells differentiated from ES cells could sustain long-lasting in vitro…
Cholesterol Biosynthesis Pathway Intermediates and Inhibitors Regulate Glucose-Stimulated Insulin Secretion and Secretory Granule Formation in Pancreatic β-Cells
Authors:Miho Tsuchiya, Masahiro Hosaka, Tomohisa Moriguchi, Shaojuan Zhang, Masayuki Suda, Hiromi Yokota-Hashimoto, Kazuo Shinozuka and Toshiyuki Takeuchi Cholesterol is reportedly abundant in the endocrine secretory granule (SG) membrane. In this study, we examined the involvement of cholesterol biosynthesis intermediates and inhibitors in insulin secretion and SG formation mechanisms. There are two routes for the…
FBS from Japan BioSerum and Biowest in Medicine and Physiology Nobel Prize 2012, winning Embryonnic Stem cell research.
Nobel Prize 2012 winning article on Stem Cells by Dr Yamanaka in magazine CELL (Volume 131 – Issue 5 – November 30, 2007 – Pages 861-872). The FBS used in the project was from Chile and Mexico, delivered by Japan BioSerum, working with Biowest for sourcing, processing and batch selection. Dr Yamanaka’s paper and poster can be found…
Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorata
Authors Yen-ying WU, Chin-chu CHEN, Charng-cherng CHYAU, Sin-yi CHUNG, Yi-wen LIU AimTo investigate the effect of water soluble-ethanol precipitation fraction (AC-1) and alkaline extraction-isoelectric precipitation fraction (AC-2) from Antrodia camphorata (Polyporaceae, Aphyllophorales) on lipopolysaccharide (LPS)-induced gene activation in mouse macrophages. MethodsThe AC-1 and AC-2 fractions were prepared, and their effects on LPSinduced gene…