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Epigenomic study identifies a novel mesenchyme homeobox2- GLI1 transcription axis involved in cancer drug resistance, overall survival and therapy prognosis in lung cancer patients
Authors:Armas López Leonel, Piña-Sánchez Patricia, Arrieta Oscar, Guzman de Alba Enrique, Ortiz Quintero Blanca, Santillán Doherty Patricio, Christiani David C., Zúñiga Joaquín and Ávila-Moreno Federico Several homeobox-related gene (HOX) transcription factors such as mesenchyme HOX-2 (MEOX2) have previously been associated with cancer drug resistance, malignant progression and/or clinical prognostic responses in lung cancer patients;…
High-Quality FBS May Come from any Authorized Country of Origin
Authors: Percy W. Hawkes, DVM Read the publication in PDF
FBS Quality vs. Countries of Origin
Authors : PERCY W. HAWKES, DVM, Regulatory Consultant, Retired Foreign Service Diplomat for USDA (APHIS) Read the article in PDF
Fetal bovine serum: geographic origin and regulatory relevance of viral contamination
Authors: Percy William Hawkes Read the publication in PDF
A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A
The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei reveals a similarity to E. coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of Gln of the…
Inhibition of Glycogen Synthase Kinase-3β Counteracts Ligand-Independent Activity of the Androgen Receptor in Castration Resistant Prostate Cancer
Authors:Stefanie V. Schütz, Andres J. Schrader, Friedemann Zengerling, Felicitas Genze, Marcus V. Cronauer, Mark Schrader In order to generate genomic signals, the androgen receptor (AR) has to be transported into the nucleus upon androgenic stimuli. However, there is evidence from in vitro experiments that in castration-resistant prostate cancer (CRPC) cells the AR is able to translocate…