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A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A
The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei reveals a similarity to E. coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells…
Inhibition of Glycogen Synthase Kinase-3β Counteracts Ligand-Independent Activity of the Androgen Receptor in Castration Resistant Prostate Cancer
Authors:Stefanie V. Schütz, Andres J. Schrader, Friedemann Zengerling, Felicitas Genze, Marcus V. Cronauer, Mark Schrader In order to generate genomic signals, the androgen receptor (AR) has to be transported…
Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro
Authors:Fuyuko Takata, Shinya Dohgu, Junichi Matsumoto, Hiroyuki Takahashi, Takashi Machida, Tomoya Wakigawa, Eriko Harada, Haruki Miyaji, Mitsuhisa Koga, Tsuyoshi Nishioku, Atsushi Yamauchi and Yasufumi Kataoka Background:Increased matrix metalloproteinase (MMP)-9…
Diamond as Functional Material for Bioelectronics and Biotechnology
Authors:Bohuslav Rezek, Marie Krátká, Egor Ukraintsev, Oleg Babchenko, Alexander Kromka, Antonín Brož and Marie Kalbacova Read the publication in PDF
Auto-Luminescent Genetically-Encoded Ratiometric Indicator for Real-Time Ca2+ Imaging at the Single Cell Level
Authors Kenta Saito, Noriyuki Hatsugai, Kazuki Horikawa, Kentaro Kobayashi, Toru Matsu-ura, Katsuhiko Mikoshiba, Takeharu Nagai BackgroundEfficient bioluminescence resonance energy transfer (BRET) from a bioluminescent protein to a fluorescent protein…
Licochalcone A Potently Inhibits Tumor Necrosis Factor α-Induced Nuclear Factor-κB Activation through the Direct Inhibition of IκB Kinase Complex Activation
Authors:Megumi Funakoshi-Tago, Saeko Tanabe, Kenji Tago, Hiroshi Itoh, Tadahiko Mashino, Yoshiko Sonoda and Tadashi Kasahara Glycyrrhiza inflata has been used as a traditional medicine with anti-inflammatory activity; however, its…
Long-term Cultures of Bone Marrow–Derived Human Mesenchymal Stem Cells Frequently Undergo Spontaneous Malignant Transformation
Authors:Gro Vatne Røsland, Agnete Svendsen, Anja Torsvik, Ewa Sobala, Emmet McCormack, Heike Immervoll, Josef Mysliwietz, Joerg-Christian Tonn, Roland Goldbrunner, Per Eystein Lønning, Rolf Bjerkvig, and Christian Schichor Human mesenchymal…
Human Hematopoietic Stem Cells Can Survive In Vitro for Several Months
Authors:Taro Ishigaki, Kazuhiro Sudo, Takashi Hiroyama, Kenichi Miharada, Haruhiko Ninomiya, Shigeru Chiba, Toshiro Nagasawa, and Yukio Nakamura We previously reported that long-lasting in vitro hematopoiesis could be achieved using…
Cholesterol Biosynthesis Pathway Intermediates and Inhibitors Regulate Glucose-Stimulated Insulin Secretion and Secretory Granule Formation in Pancreatic β-Cells
Authors:Miho Tsuchiya, Masahiro Hosaka, Tomohisa Moriguchi, Shaojuan Zhang, Masayuki Suda, Hiromi Yokota-Hashimoto, Kazuo Shinozuka and Toshiyuki Takeuchi Cholesterol is reportedly abundant in the endocrine secretory granule (SG) membrane. In…
FBS from Japan BioSerum and Biowest in Medicine and Physiology Nobel Prize 2012, winning Embryonnic Stem cell research.
Nobel Prize 2012 winning article on Stem Cells by Dr Yamanaka in magazine CELL (Volume 131 – Issue 5 – November 30, 2007 – Pages 861-872). The FBS used in the project…
Modulation of inflammation-related genes of polysaccharides fractionated from mycelia of medicinal basidiomycete Antrodia camphorata
Authors Yen-ying WU, Chin-chu CHEN, Charng-cherng CHYAU, Sin-yi CHUNG, Yi-wen LIU AimTo investigate the effect of water soluble-ethanol precipitation fraction (AC-1) and alkaline extraction-isoelectric precipitation fraction (AC-2) from Antrodia…
The study of the interaction of human mesenchymal stem cells and monocytes/macrophages with single-walled carbon nanotube films
Authors M. Kalbacova, M. Kalbac, L. Dunsch, H. Kataura, and U. Hempel The influence of single-walled carbon nanotube (SWCNT) films on two different human cell types was investigated: primary…